Stage-specific antibody response against two larval stages of Brugia malayi in different clinical spectra of brugian filariasis
Identifieur interne : 000168 ( Main/Exploration ); précédent : 000167; suivant : 000169Stage-specific antibody response against two larval stages of Brugia malayi in different clinical spectra of brugian filariasis
Auteurs : Praveen Kumar Tripathi [Inde] ; Ramesh Chander Mahajan [Inde] ; Nancy Malla [Inde] ; Naveen Kumar [Inde] ; Shailja Misra Bhattacharya [Inde] ; Ranganatha Krishna Shinoy [Inde] ; Abhishek Mewara [Inde] ; Rakesh Sehgal [Inde]Source :
- Tropical Parasitology [ 2229-5070 ] ; 2017.
Abstract
T-cell hypo-responsiveness in microfilaria (Mf) carriers against the microfilarial stage antigen of
The work was carried out with the aim to assess stage-specific antibody responses against L3 and microfilarial stage antigens in brugian filariasis in an endemic area.
Patients with different clinical spectra of brugian filariasis were recruited to evaluate antibody responses to brugian antigens.
Serum samples were collected from patients with different clinical spectra and antibody response was evaluated for total immunoglobulin G (IgG), IgG isotypes (IgG1, IgG2, IgG3, IgG4) and immunoglobulin E (IgE) response to L3 and microfilarial stage by enzyme-linked immunosorbent assay.
Paired t-test and one-way analysis of variance were carried out to analyze the data.
L3 and microfilarial stage antigens showed almost similar antibody responses in adenolymphangitis (ADL) and chronic pathology (CP) patients, however, diminished antibody response was observed with Mf stage antigen, especially with microfilaraemia. ADL patients had minimum antibody levels of all isotypes except IgG2 on day 0 which showed an increase subsequently, indicating suppression of antibody response during filarial fever. CP patients showed increase in IgE and decrease in IgG4 antibodies on day 365 indicating that these differences may be due to recent conversion into CP.
A prominent hyporesponsiveness in microfilaraemic individuals against microfilarial stage, but not against the L3 stage of the same parasite was observed, concluding stage-specificity in humoral immune response in brugian filariasis.
Url:
DOI: 10.4103/2229-5070.202298
PubMed: 28459012
PubMed Central: 5369271
Affiliations:
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different clinical spectra of brugian filariasis</title><author><name sortKey="Tripathi, Praveen Kumar" sort="Tripathi, Praveen Kumar" uniqKey="Tripathi P" first="Praveen Kumar" last="Tripathi">Praveen Kumar Tripathi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh</wicri:regionArea><wicri:noRegion>Chandigarh</wicri:noRegion></affiliation></author><author><name sortKey="Mahajan, Ramesh Chander" sort="Mahajan, Ramesh Chander" uniqKey="Mahajan R" first="Ramesh Chander" last="Mahajan">Ramesh Chander Mahajan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India</nlm:aff><country 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of Medical Education and Research, Chandigarh, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh</wicri:regionArea><wicri:noRegion>Chandigarh</wicri:noRegion></affiliation></author><author><name sortKey="Bhattacharya, Shailja Misra" sort="Bhattacharya, Shailja Misra" uniqKey="Bhattacharya S" first="Shailja Misra" last="Bhattacharya">Shailja Misra Bhattacharya</name><affiliation wicri:level="1"><nlm:aff id="aff2">Division of Parasitology, CDRI, Lucknow, Uttar Pradesh, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Division of Parasitology, CDRI, Lucknow, Uttar Pradesh</wicri:regionArea><wicri:noRegion>Uttar Pradesh</wicri:noRegion></affiliation></author><author><name sortKey="Shinoy, Ranganatha Krishna" sort="Shinoy, Ranganatha Krishna" uniqKey="Shinoy R" first="Ranganatha Krishna" last="Shinoy">Ranganatha Krishna Shinoy</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Medicine, Filariasis Chemotherapy Unit, TD Medical College Hospital, Alappuzha, Kerala, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medicine, Filariasis Chemotherapy Unit, TD Medical College Hospital, Alappuzha, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Mewara, Abhishek" sort="Mewara, Abhishek" uniqKey="Mewara A" first="Abhishek" last="Mewara">Abhishek Mewara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh</wicri:regionArea><wicri:noRegion>Chandigarh</wicri:noRegion></affiliation></author><author><name sortKey="Sehgal, Rakesh" sort="Sehgal, Rakesh" uniqKey="Sehgal R" first="Rakesh" last="Sehgal">Rakesh Sehgal</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh</wicri:regionArea><wicri:noRegion>Chandigarh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Tropical Parasitology</title><idno type="ISSN">2229-5070</idno><idno type="eISSN">2229-7758</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Context:</title><p>T-cell hypo-responsiveness in microfilaria (Mf) carriers against the microfilarial stage antigen of <italic>Brugia malayi</italic> has been described, but no study has been carried out to assess antibody dynamics against stage-specific antigens.</p></sec><sec id="st2"><title>Aim:</title><p>The work was carried out with the aim to assess stage-specific antibody responses against L3 and microfilarial stage antigens in brugian filariasis in an endemic area.</p></sec><sec id="st3"><title>Setting and Design:</title><p>Patients with different clinical spectra of brugian filariasis were recruited to evaluate antibody responses to brugian antigens.</p></sec><sec id="st4"><title>Subjects and Methods:</title><p>Serum samples were collected from patients with different clinical spectra and antibody response was evaluated for total immunoglobulin G (IgG), IgG isotypes (IgG1, IgG2, IgG3, IgG4) and immunoglobulin E (IgE) response to L3 and microfilarial stage by enzyme-linked immunosorbent assay.</p></sec><sec id="st5"><title>Statistical Analysis:</title><p>Paired t-test and one-way analysis of variance were carried out to analyze the data.</p></sec><sec id="st6"><title>Results:</title><p>L3 and microfilarial stage antigens showed almost similar antibody responses in adenolymphangitis (ADL) and chronic pathology (CP) patients, however, diminished antibody response was observed with Mf stage antigen, especially with microfilaraemia. ADL patients had minimum antibody levels of all isotypes except IgG2 on day 0 which showed an increase subsequently, indicating suppression of antibody response during filarial fever. CP patients showed increase in IgE and decrease in IgG4 antibodies on day 365 indicating that these differences may be due to recent conversion into CP.</p></sec><sec id="st7"><title>Conclusion:</title><p>A prominent hyporesponsiveness in microfilaraemic individuals against microfilarial stage, but not against the L3 stage of the same parasite was observed, concluding stage-specificity in humoral immune response in brugian filariasis.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wammes, Lj" uniqKey="Wammes L">LJ Wammes</name></author><author><name sortKey="Hamid, F" uniqKey="Hamid F">F Hamid</name></author><author><name sortKey="Wiria, Ae" uniqKey="Wiria A">AE Wiria</name></author><author><name sortKey="Wibowo, H" uniqKey="Wibowo H">H Wibowo</name></author><author><name sortKey="Sartono, E" uniqKey="Sartono E">E Sartono</name></author><author><name sortKey="Maizels, Rm" 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sort="Kumar, Naveen" uniqKey="Kumar N" first="Naveen" last="Kumar">Naveen Kumar</name><name sortKey="Mahajan, Ramesh Chander" sort="Mahajan, Ramesh Chander" uniqKey="Mahajan R" first="Ramesh Chander" last="Mahajan">Ramesh Chander Mahajan</name><name sortKey="Malla, Nancy" sort="Malla, Nancy" uniqKey="Malla N" first="Nancy" last="Malla">Nancy Malla</name><name sortKey="Mewara, Abhishek" sort="Mewara, Abhishek" uniqKey="Mewara A" first="Abhishek" last="Mewara">Abhishek Mewara</name><name sortKey="Sehgal, Rakesh" sort="Sehgal, Rakesh" uniqKey="Sehgal R" first="Rakesh" last="Sehgal">Rakesh Sehgal</name><name sortKey="Shinoy, Ranganatha Krishna" sort="Shinoy, Ranganatha Krishna" uniqKey="Shinoy R" first="Ranganatha Krishna" last="Shinoy">Ranganatha Krishna Shinoy</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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